Chau Nguyen, PhD

Dr. Nguyen joined the D'Youville School of Pharmacy in 2010 after completing a Postdoctoral Fellowship at Western University.  He is the recipient of a number of research awards and is a co-inventor of a patented research technology.  He has served as a peer-reviewer of research grants and scientific manuscripts and is a member of the American Association of Colleges of Pharmacy.  Dr. Nguyen enjoys outdoor activities with family and friends in his spare time

• PhD, Molecular Pharmacology, Purdue University, 2006
• BSc, Pharmacology & Toxicology, University of Western Ontario, 2001

• Faculty inductee, Rho Chi Honor Society in Pharmacy, 2019
• School of Pharmacy Distinguished Faculty of the Year, 2015
• Departmental Faculty of the Year, 2014

My research interests focus on a family of proteins known as the Regulator of G protein Signaling (RGS) proteins. The goal of this work is to better understand the molecular basis of human diseases with the hope of identifying novel therapeutic targets. My specific areas of interests include neuropsychiatric disorders and cardiovascular diseases.

• Lee KN, Lu X, Nguyen C, Feng Q, Chidiac P. Cardiomyocyte specific overexpression of a 37 amino acid domain of regulator of G protein signalling 2 inhibits cardiac hypertrophy and improves function in response to pressure overload in mice. Journal of Molecular and Cellular Cardiology. 2017; 108: 194-202.
• Chidiac P, Sobiesiak AJ, Lee KN, Gros R, Nguyen CH. The eIF2B-interacting domain of RGS2 protects against GPCR agonist-induced hypertrophy in neonatal rat cardiomyocytes. Cellular Signalling. 2014; 26: 1226-34.
• Nguyen CH, Zhao P, Sobiesiak AJ, Chidiac P. RGS2 is a component of the cellular stress response. Biochemical and Biophysical Research Communications. 2012; 426(1): 129-34.
• Zhao P, Nguyen CH, Chidiac P. The proline-rich N-terminal domain of G18 Exhibits a novel G protein regulatory function. Journal of Biological Chemistry. 2010; 285(12): 9008-17.
• Nguyen CH, Ming H, Zhao P, Hugendubler L, Gros R, Kimball SR, Chidiac P. Translational control by RGS2. Journal of Cell Biology. 2009; 186(5): 75-85.
• Chester JA, Mullins AJ, Nguyen CH, Watts VJ, and Meisel RL. Repeated quinpirole treatments produce neurochemical sensitization and associated behavioral changes in female hamsters. Psychopharmacology (Berl). 2006; 188(1): 53-62.
• Nguyen CH and Watts VJ. Dexamethasone-induced Ras protein 1 negatively regulates protein kinase C delta: implications for adenylyl cyclase 2 signaling. Molecular Pharmacology. 2006; 69(5): 1763-71.
• Vortherms TA, Nguyen CH, Bastepe M, Juppner H, and Watts VJ. D2 dopamine receptor-induced sensitization of adenylyl cyclase type 1 is Galpha(s) independent. Neuropharmacology. 2006; 50(5): 576-84.
• Nguyen CH and Watts VJ. Dexras1 blocks receptor-mediated heterologous sensitization of adenylyl cyclase 1. Biochemical and Biophysical Research Communications. 2005; 332(3): 913-20.
• Vortherms TA, Nguyen CH, Berlot CH, and Watts VJ. Using molecular tools to dissect the role of Galphas in sensitization of AC1. Molecular Pharmacology. 2004; 66(6): 1617-24.